Due to many vast application of C-C bond formation in the areas including bioactive compounds, natural products and high performance materials, over the past few years, the C-C coupling reactions have become a versatile tool in organic synthesis. One of the most efficient methods in this category is Sonogashira coupling reaction. In this work the application of a new, efficient and inexpensive ionic liquid; copper(I) chlorid /Cholin chlorid is studied. The ionic liquid; catalytic system has been developed to catalyze ligand and palladium-free Sonogashira coupling reactions of phenylacetylenes with a variety of aryl halides to afford the corresponding coupling products in 18-97% yields. The present catalytic system appears attractive in view of its ease of application and low cost, due to the use of a readily available non-noble metal catalyst combined with the absence of ligands. We found that electron-withdrawing and donating substituents on aryl halides enhanced the coupling of aryl halides with phenyl acetylenes. Excellent yield of the Sonogashira reaction catalyzed by 20 mol% ionic liquid could be achieved at 140 °C and DMF as the solvent within 2-10 hours. Solid-state or solvent-free reactions are called green or clean reactions because organic solvents are not used in these reactions. In the next section, Stable and non-hygroscopic Fe/ZrCe and Zn/ZrP, which are prepared easily and commercially available compounds was found to be an effective catalyst for Friedel–Crafts acylation reactions using carboxylic acids, acetic anhydride and benzoyl chloride in the absence of solvent under mild reaction conditions. Both catalyst aromatic carboxylic acids reacted easily to afford the corresponding aromatic ketones. The use of non-toxic and inexpensive materials, simple and clean work-up, short reaction times and good yields of the products are the advantages of this method. For these reactions 1 H-NMR, 13 C-NMR, FT-IR and GC technologies were used