Due to the development of green chemistry in recent years, researchers have been interested in the application of ionic liquids instead of common organic solvents. Ionic liquids can also apply as green catalysts. Ionic liquid have remarkable properties such as non-flammable, high thermal stability, negligible vapor pressure, easy recyclability and high solvating ability. In recent years, ionic liquids containing Choline chloride as an inexpensive and biodegradable compound, have attracted a lot of attentions. One pot multi-component reactions, due to their simple and mild reaction condition, energy saving and environmental compatibility are very important in carbon-carbon and carbon-heteroatom bond formation. Researches in organic chemistry have expanded the one-pot multi-component reactions according to green chemistry purposes. Solid-state or solvent-free reactions are called green or clean reactions because organic solvents are not used in these reactions. ?-amino nitriles are important intermediates for the preparation of many amino acids and various nitrogen containing heterocycles and other pharmacologically useful molecules. Because of their wide range of applications these compounds have received a great deal of attention in recent years in connection with their synthesis. Among various methods reported in the literature for the preparation of ?-amino nitriles, the most important route for the synthesis of them is the Strecker reaction. In this reaction, ?-amino nitriles are synthesized by three component condensation of carbonyl compounds (aldehydes or ketones), amine and a cyanid source. Due to many vast application of C-C bond formation in the areas including bioactive compounds, natural products and high performance materials, over the past few years, the C-C coupling reactions have become a versatile tool in organic synthesis. The cross-coupling of aryl halides with arylboronicacids namely Suzuki–Miyaura coupling reaction has become one of the most powerful, versatile and popular tools for the selective construction of carbon-carbon bonds. The fact that the products of this reaction are biaryls, which are important structural moieties in numerous polymers, agrochemicals, natural products and pharmaceutical intermediates has made it an important and common tool in organic synthesis. In the past two decades, efforts have been made to develop efficient catalytic systems for the Suzuki–Miyaura coupling reaction. Herein, we synthesized an inexpensive and biodegradable Lewis acidic ionic liquid using Choline chloride and ZnCl 2 and then we applied it in synthesis of ?-amino nitriles. In this reaction, various aldehydes and ketones were reacted with aniline and trimethylsilylcyanide (TMSCN) to afford the corresponding ?-amino nitriles in high yields. The advantage of this ionic liquid was its application for acid sensitive heterocycles, which yielded the corresponding ?-amino nitriles without any polymerization. In the next section, an efficient and effective palladium salt was synthesized using the salt of 1-benzyl-4-aza-1-azoniabicyclo [2.2.2] octane chloride (n-benzyl DABCO chloride) and palladium chloride. This palladium salt was applied in Suzuki reaction as the catalyst. In this reaction, various aryl iodides and aryl bromides were coupled with arylboronic acids at room temperature and in ethanol as a green solvent and in the presence of K 2 CO 3 as the base. Afterwards, by changing the reaction condition and adding tetrabutylammonium bromide, the palladium salt was applied in the synthesis of biphenyls from aryl chlorides, which are cheaper and more available.The applied palladium salt was oxygen resistant, so all reactions were performed under air atmosphere.