The increasing demand for energy in the world and reduction of oil resources as well as environmental pollution have attracted attention to the development of alternative sustainable energy sources. Biofuels production from lignocellulosic materials have a high potential for use as renewable resources. In this regard, the construction of biorefineries with the capability of converting lignocellulosic biomass to energy and high value-added materials seems to be a good solution. In this research, the possibility of developing a biorefinery based on date palm wastes was investigated. For this purpose, date and lignocellulosic date palm wastes, including trunk, seed, pedicel, leaf, and leaf sheath were first subjected to phosphoric acid, organic solvent, and hot water pretreatment. The effect of each pretreatment was then evaluated on hydrolysis, fermentation, and biogas production. Phosphoric acid pretreatment was carried out at the temperature of 50 for 45 min and organosolv and hot water pretreatments were performed at 180 for 60 min. In order to determine the amount of released sugar, both untreated and pretreated samples were hydrolyzed using 15 FPU/g Cellic Ctec2 commercial enzyme. Biogas production results showed that for trunk and pedicel, organosolv pretreatment in the presence of sulfuric acid as a catalyst was the most effective treatment and produced 63.9 and 82.2 ml methane/g VS, respectively, after 40 days of anaerobic digestion. The best pretreatment for leaf and leaf sheath in biogas production was phosphoric acid pretreatment and produced 100.5 and 114.1 ml methane/g VS, respectively. However, the methane yield from seed and date was not improved by the pretreatments. In enzymatic hydrolysis for leaf and seed, phosphoric acid pretreatment resulted in the maximum fermentable sugars production of 14.4 and 6.6 g/L, respectively. For trunk, organosolv pretreatment was the most effective and produced 14.7 g/L glucose. For leaf sheath and pedicel organosolv pretreatment with catalyst was the best and produced 34/0 and 12.8 g/L glucose, respectively. For date hydrolysis, none of the pretreatments were effective. Results of F showed that all pretreatments were effective in the production of ethanol for trunk, leaf sheath, pedicels, leaf, and seed, and the highest ethanol yields were 33.7, 57.0, 30.0, 53.3, and 70.6%, respectively, while pretreatments in the production of ethanol from date were not successful and the highest ethanol concentration was related to untreated sample.