Salinity and zinc (Zn) deficiency are two growth and yield limiting factors in most arable lands in Iran . This hydroponics study was conducted to investigate the response of bread wheat genotypes (Triticum aestivum L. cvs. Kavir, Rushan and Cross) to oxidative stress induced by Zn deficiency and salinity at three salinity levels (0, 60, and 120 mM NaCl) and two levels of Zn (0 and 1 µM in the form of ZnSO4). During the plant growth, the phytosiderophore released by the roots was collected and measured using the method of Cu mobilization from the resin. The root leakage was collected and K, Fe, Zn, and Mn concentrations of the leakage were measured. After plant harvesting, shoot and root dry matter yield as well as root and shoot concentrations of K, Na, Ca, Mg, P, Fe, Zn, Mn and Cu were measured. In addition, root cell-membrane permeability and reactive sulfhydryl groups concentrations were determined. Zinc application significantly decreased the root dry matter yield whereas it had no effect on the shoot dry matter weight. Salinity had negative effect on the shoot and root dry matter yield. Zinc deficiency had no effect on the root membrane permeability and concentration of reactive sulfhydryl groups in all wheat genotypes. By increasing salinity, the root membrane permeability and the concentration of reactive sulfhydryl groups significantly increased in all wheat genotypes. The Fe concentration in the root leakage decreased by Zn application in the Kavir plants. In contrast, salinity increased concentrations of K, Fe, Zn, and Mn in the root leakage in all wheat genotypes. The 120 mM NaCl treatment increased significantly the concentrations of reactive sulfhydryl groups. Zinc nutrition increased the root and shoot Na, Mg and Zn concentrations whereas it reduced the root and shoot concentrations of Fe. The root concentrations of K and Mg and the shoot concentrations of Ca and Mg decreased by increasing salinity while shoot K, Na, P, Fe, Zn, and Mn concentrations and root Ca, Cu, Na, P, Fe, Zn, and Mn increased by salinity. In all wheat genotypes, Zn application increased the Na, Mg, and Zn concentrations while decreased the Fe concentration in the root and shoot. The effect of Zn deficiency and salinity on the phytosiderophore release varied among wheat genotypes. Zinc application increased phytosiderophore release in the Rushan plants while it had no significant effect on the phytosiderophore release in the Kavir and Cross genotypes. Both in the Rushan and Kavir genotypes, salinity increased the phytosiderophore exudation whereas the Cross genotype released less amount of phytosiderophore under saline conditions. Key words: Salinity, Phytosiderophore, Zinc efficiency, Leakage