The method of geochemical exploration of stream sediments is one of the most widely used methods in the preliminary stages of exploration. In this method, the sample catchment basin is defined by determining the upstream area affected by the sediment composition. One of the important challenges in the method of stream sediments is to determine the origin of anomalies, which in most mineral studies leads to the discovery of the ore. Two methods of multiple regression and weighted mean are used to determine the anomaly in the sample catchment basin approach. In both of these methods, anomalous basins are determined by estimating the amount of geochemical background of rock units and eliminating their effect on the concentration of stream sediments taken. It can be said that the estimation of geochemical background of rock units and the determination of the anomalous basins are two very important processes in the sample catchment basin approach. In this study, multiple regression and weighted mean methods were compared to determine which of the two methods performed more successfully in the two processes. For this purpose, data from 1: 100000 Anarak sheet and data from Feshark region in 1: 100000 Kuhpayeh sheet were used. Using data from Anarak sheet and determining the anomalous basin using both methods and using the existing mineral deposits in this sheet, it has been determined that multiple regression method are more successful in this regard. In fact, among the six elements studied, in three cases, the multiple regression method and in both cases, the weighted mean method was superior, and in the other case, both methods yielded approximately the same results. Also, with the availability of the actual value of geochemical background and the relative weathering rate of the rock units in the Feshark region, the amount of geochemical background of rock units in this region and the concentration of the outputs of each basin were estimated. By comparing the estimated values ??of both methods with the actual value, it was determined that the weighted mean method for most of the elements studied estimated the geochemical background of rock units with higher precision and accuracy, but the range of estimates changes in the multiple regression method to the range of changes actual values ??are closer. However, the multiple regression method, estimates the outputs ??of each basin for all the elements studied with higher precision and accuracy and range of changes closer to the range of actual values.