Nitrate and ammonium as nitrogen source were used by microalgae in waterbodies. They play important role either in removing of nitrogenous compounds or in production of useful algal biomass. The species with high tolerance for nitrogen compounds are useful in order to treating nitrogen-rich wastewaters. These benefits make microalgae as practical organisms in aquaculture activities. Therefore, introduction of the indigenous microalgae named Scenedesmus quadricauda, which has suitable growth and reproduction on nitrogen-rich wastewaters, was selected for this research. In this research, firstly S. quadricauda was cultured under different nitrate and ammonium levels (2.9 to 150 mM) as nutrient, and then in another experiment, efficiency of this algae was examined in order to remove ammonia and nitrite compounds from fish farm effluent. Results showed that dry-biomass of S. quadricauda for 2.9, 25, 50, 75, 100 and 150 mM of NaNO 3 were 0.89, 0.86, 0.48, 0.48, 0.26 and 0.22 mg/ml, respectively, while for the same concentration of NH 4 Cl, dry-biomass were 0.89, 0.76, 0.53, 0.38, 0.38 and 0.31 mg/ml, respectively. In the other hand, specific growth rate (SGR) for the same concentration of NaNO 3 were 0.065, 0.063, 0.015, 0.015, -0.045 and -0.065 day -1 , respectively, while in the same concentration of NH 4 Cl, SGR were 0.065, 0.053, 0.023, -0.003, -0.003 and -0.023 day -1 , respectively. Dry-biomass of S. quadricauda for 2.9, 5, 10, 15, 20 and 25 mM of NaNO 3 were 0.54, 0.68, 0.75, 0.78, 0.68 and 0.50 mg/ml, respectively, while for the same concentration of NH 4 Cl, dry-biomass were 0.54, 0.65, 0.50, 0.39, 0.38 and 0.37 mg/ml, respectively. SGR for the similar concentration of NaNO 3 were 0.192, 0.230, 0.240, 0.273, 0.260 and 0.185 day -1 , respectively, while for the same concentration of NH 4 Cl, SGR were 0.192, 0.143, 0.143, 0.170, 0.083 and 0.059 day -1 , respectively. Therefore, the best range for growth of this algae is between 2.9 to 25 mM of NaNO 3 and NH 4 Cl, while the optimum concentration of NaNO 3 and NH 4 Cl was obtained 15 mM. In this concentration, S. quadricauda had maximum SGR (0.27day -1 ) and minimum population doubling time (DT) (2.54 day). Our findings about culture of S. quadricauda on different wastewater treatments indicated that better growth performance obtained with diluted fish farm effluent (ammonia=0.11mg/L, nitrite=0.62 mg/L). In these conditions, maximum cell number (9×10 6 cell/ml), maximum chlorophyll a (2.90 mg/L), and better ammonia (89.57%) and nitrite (89.53%) removing were found. Results of this research indicated that S. tanks. .