Various kinds of artificial prosthesis have been used to repair the bone damages when the bone structure and tissue can not be regenerated and repaired themselves. The artificial prosthesis makes movement difficulties and inflammation for the patients. Tissue engineering methods have been experienced to regenerate bone tissue by nano fibrous scaffolds and implant it to the damaged member. Previous attempts have been limited by problems in infiltration of bone cells into the scaffold. In the present research scaffolds for bone tissue engineering have been fabricated by bicomponent electrospinning of PCL and Gelatin nanofibers and the Gelatin nanofibers were dissolved in distilled water and eliminated from scaffold to manufacture an ultra porous scaffold with pore size many times more than bone cell size. The results of porosity estimation by both methods of density measurement and image processing of SEM images presented that generated pore size on scaffolds are very suitable for cell infiltration. Also, nanofibers diameter sizes and distributions are very suitable while the strengths of scaffolds are acceptable for bone tissue engineering. Keywords: Tissue engineering, Bic omponent electrospinning, Scaffold, Poly caprolactone nanofibers, Gelatin nanofibers
