Plastic injection processes comprise plastication, injection, packing, cooling and ejection. Due to the existence of competitive conditions a fast, cheap, and high quality of products are the mail advantages of any producer. To end this, the computer analysis and engineering software is used to facilate the design and manufacturing of plastic parts. For analyzing the injection molding process, one of the commercial analytical software is Mold flow. In this study, two parts one with holes and the other with pins with half-millimeter wall thickness are considered. The parameters of the melt temperature, mold temperature, injection pressure, holding pressure, holding pressure and cooling time were considered as parameter variables. Using the design of experiment method (Taguchi methodology) and analysis of variance, the effect of the parameters on the warpage of the components was investigated. Further, optimal values ??for process parameters were determined. For the desired parts, a plastic injection mold was designed and manufactured. Finally, the values ??obtained from the simulation results were compared with the components produced by the plastic injection molding. By comparing the experimental and numerical results, the methodology used in this study is confirmed. According to simulation and experimental results, the amount of warpage in part with holes was higher. It also shows that by using this method, the amount of warpage in components decreased by 68%. Keywords: Injection molding process, Warpage, Design of experiment, Analysis of variance, Mold flow