Shadan region is a part of Lut Block and East Iran Belt located 65 Km west of Birjand (South Khorasan Province). The correct decision could have a significant effect on exploration projects. The main object of this study is combination of new methods and integration of various exploration data in a GIS environment to identify areas of high mineral potential for further drillings. The input data layers for GIS integration are composed of lithologic maps, alteration, geophysical and geochemical layers and tectonics. This area consisting of outcrop of Eocene volcanic unit and also Oligo- Miocene intrusive masses. In this research using techniques of processing ETM + and Aster satellite data include combining false colored (RGB), band ratio, least squares regression (LS-Fit) and principle component analysis (PCA) some alteration including argillic, propylitic, phylic and zones containing iron oxides that can be directly or indirectly related to the mineralization identified and introduced. In the next step, using the results of chemical analysis of 46 elemente by ICP, 297 rock samples of Shadan area were analyzed. First univariate statistical analysis was performed on the data and single- element halo of gold, cooper and molybdenum maps were prepared. Then multivariate studies included factor analysis, cluster analysis and geochemistry mineralization probability index (GMPI) was performed between elements and important factor of the framework map was presented. In the next step, a magnetic survey carried out in the study area and the total magnetic field intensity were measured. The total magnetic field intensity were measured at 547 stations. Then using Genetic Algorithm and Geosoft Software the magnetic maps were mapped. Finally, two new combination methods of Fuzzy Logic and TOPSIS were used in this research to create final mineral potential map for further drillings at the Shadan area. The result showed that these two methods support and complete each other. But TOPSIS method proved to be the best method for combining the exploration data. Comparing the final integrated potential maps with the field evidences, mineralized locations and also analytical results of 6 boreholes confirm the importance of TOPSIS method in this regards.