: High energy consumption and low energy efficiency of distillation systems have led to extensive research to improve the performance of these systems. In this study, vapor recompression and bottom flashing systems have been investigated and some configurations have been proposed to improve their efficiency. In the first part of this study, several configurations of vapor recompression that were previously presented were compared and the configurations that showed the highest efficiency in reducing energy consumption and process costs were identified. In addition, the strengths and weaknesses of each of the previous plans were determined. Using the ideas and schemes, a new system for the purification of sour water was presented and the results of this section showed that using the concepts of vapor recompression heat pump, significantl reduction of energy consumption and costs in various chemical processes can be obtained. Based on the results, using the proposed system in the process of sour water stripping, 83.7% and 77.8% can be saved in heating and cooling utilities, respectively. In another section, the ideas and designs that were proposed for vapor recompression were developed for use in the bottom flashing and the results showed that the bottom flashing with heating recuperation could outperform vapor recompression system. Based on this, the use of the developed system of bottom flashing on the distillation of isobutane-normal butane has completely eliminated cooling sources and reduced 98.6% of the heating resources in the system. It also reduced the total annual cost of the process by 19% compared with the typical distillation tower. Meanwhile, based on the concepts of vapor recompression and sudden product evaporation, systems for the complex separation of three products, such as direct sequencing, indirect sequencing, Petlyuk and side stripper designs, were developed. In five of the configurations, designed in this section, including a DBF with direct, Petlyuk and side stripper and VRC with Petlyuk and side stripper, the complete elimination of heating supplies were obtained, and in the system of DBF- direct sequence 95.8% reduction of cooling sources was obtained. Economic analysis also revealed that all designed systems of vapor recompression and bottom flashin improved the efficiency of the base system, and using a system of bottom flashing on the Petlyuk arrangement, a 30.9% decrease in total annual cost of the process is achievable. Finally, with the use of the main concepts of steam condensation, a new distillation system was established that does not require any use of heating resources in the system, and uses water at ambient temperature as the only source of heat in the system. The results showed that the proposed system could, in addition to the complete removal of heating resources, reduce the required cooling utilities and electrical power requirements compared to the vapor recompression system. By applying this configuration, on the propylene-propane distillation tower, a reduction of 17.6% in total annual cost of the process was achieved. Key words : Distillation, Energy, Vapor recompression, Bottom flashing, Configuration.