In this work, zinc oxid quantum dots (ZnO-QDs) were used in order to determination of chlorogenic acid (CGA). At the first step of this work, ZnO-QDs were prepared using sol-gel method. At the next step, a thin film of silica was formed by reverse microemulsion technique on the surface of ZnO-QDs. Finally, Molecularly Imprinted Polymer (MIP) embedded ZnO-QDs were obtained. In this step, 3-aminopropyltriethoxysilane (APTES) and tetraethoxysilane (TEOS) were applied as a functional monomer and a cross linker, respectively. Different variables affecting the optical signal were optimized. Under the optimal conditions, linear dynamic range of the optical sensor was 0.2 to 5.3 mg L –1 CGA with a detection limit 0.06 mg L –1 . The response of the optical sensor for common biological media was investigated. The results confirmed the good selectivity of the sensor for the measurement of CGA. In the second work, a novel selective green and eco-friendly carbon dots were synthesized from Eucalyptus leaves as a carbon dots (CDs) source via hydrothermal method. The MIPs was prepared via microemulsion method on to the surface of the CDs. Under the optimized e xperimental parameters such as pH, amount of CDs@MIPs, temperature and time, metronidazole could be detected in the linear dynamic range from 0.4 to 10 ?g L -1 with a detection limit as 0.2 ?g L -1 . This sensor have many advantages such as green, simple and non-expensive synthesis method.
