: The water crisis is one of the challenges of the present century that could be the source of many positive and negative evolutions in the very near future. Iran, with its current population year, but if the current trend of population growth continues, the per capita of more than 80 million, has about 2000 cubic meters of water per capita per to the management of water resources and in particular the phenomenon of river water level per year will be less than 1000 cubic meter per year. Therefore, it is important to pay attention drainage and its multiple effects on the life of the inhabitants of the people of East Isfahan. At first, with the help of spatial information and surrounding areas. The main purpose of this study was investigating the economic, social and psychological effects of drying up of Zayanderud is affecting the studied. Also, the satellite data, land use changes in the pre- and post-drought conditions were Keywords : Drought, Impact assessment, Zayanderud, East Isfahan.