Membranetechnology is getting more attractiveprocessforthe oil,petrochemicalandgas industriesin comparison with otherknowntechnologiessuch asabsorptionanddistillationprocesses.This is due to the facts that the membrane processes are less expensive and energy efficient and environmental friendly. However,some membrane properties such as high selectivity and permeability limit their applications. There is, therefore, need of membrane with high permeability and selectivity, chemical mechanical and thermal stability cause development in different base membrane.In the present study, the separation of oxygen, nitrogen, methane and carbon dioxide gases by using Polysulfone/Hexamethylenetetramine Dicyanamide Cadmium (PSF-MOF*) nano composite different base membranes were investigated.All different base(PSF-MOF*)membraneswere preparedbysolventevaporationmethodusingphaseseparation.The prepared nano composite membranes were characterized by Fourier transform infrared spectroscopy (FTIR) and Scanning electron microscopy (SEM) tests.The obtained characterization results revealed that the Hexamethylenetetramine Dicyanamide Cadmium nano particles were compatible with polymer matrix well and homogenously distributed in the matrix.The performances of prepared membranes in gas separation were evaluated at pressure of 10 barg and temperature of 30 ?C. The obtained results showed that in the present of Hexamethylenetetramine Dicyanamide Cadmium nano particles in polysulfone structure, the permeability of carbon dioxide, oxygen, nitrogen and methane gases decreased respectively from 6.16, 1.57, 0.49 and 0.21 Barrer in pure PSF to 5.00, 1.26, 0.29 and 0.12 Barrer in the Nano composite membrane containing 2.5%wt Hexamethylenetetramine Dicyanamide Cadmium particles. The permeability values decreased 18.84%, 24.6%, 40.81% and 42.85% respectively.Also the performances of separation of CO 2 from CH 4 , separation of CO 2 from N 2 and separation of O 2 from N 2 were increased by adding Hexamethylenetetramine Dicyanamide Cadmium nanoparticles in PSF matrix,The maximum selectivities of CO 2 /CH 4 , CO 2 /N 2 and O 2 /N 2 were measured as 41.56, 20.01 and 5.07 in the Nano composite membrane containing 2.5%wt Hexamethylenetetramine Dicyanamide Cadmium particles, respectively. Based on theseresults and as well as Robsoncurves, it is determined that themixed matrix membranewith2.5wt%HexamethylenetetraamineDicyanamideCadmium in comparison with lowercontent wasthe best procedure for separating process. Keyword: Polysulfone, Gas separation, Polysulfone Membrane, Mixed Martix Membrane, Hexamethylenetetramine Dicyanamide Particle.