Presence of weeds and their competition with crop is a major factor that cause reduction in crop quality and yield. Priming of seed improves seedling establishment and germination and increases competition ability of crops with weeds. In this study the effects of alachlor (3.5 ,5 l/ha ) and trifloralin (1.5, 2.5 l/h) as pre-emergence and bentazon (.75 , 1 l/ha) and haloxyfop (2, 3 l/ht) as post-emergence herbicides and their combination along with the effect of seed hydropriming on weed control and growth and yield of sesame were studied at the Lavark Reasearch Farm, Isfahaan University of Technology, Isfahan, Iran in 2010. Thirteen herbicide treatments along with weed control free and hand weeded control were evaluated using a factorial experiment based on a randomized complete block design with three replications . Hydropriming reduced days from planting to seedling establishment, increased seedling dry weight and the crop grain yield. Amaranthus retroflexus, Echinochola crus-galli and Chenopodium album were dominant weeds. The combination of Bentazon and alachlor and bentazon with trifloralin were the most effective treatments in reducing the number of weeds and increasing the grain yield. The interaction between herbicide rate and priming was significant for non of the traits. However, a significant interaction was found between priming and herbicide for the grain yield. Hydropriming with pre-emergence alachlor (3.5, 5 l/ha), trifloralin (1.5 l/ha) and their combination with haloxyfop increased the grain yield of sesame. Application of 2.5 l/ha of trifloralin caused significant damages to sesame crop. Application of bentazon with pre-emergence herbicides significantly controlled the weeds, but it caused substantial damages to sesame crop. The lowest seed yield was obtained with the post-emergence herbicides and their combimation. The results showed that hydropriming alone had no effect on weed control, but increased the sesame yield. In order to effectively control the weeds in sesame, application of alachlor (3.5, 5 l/ha) with trifloralin ( 1/5 l/ha) or their combination with haloxyfop along with hydropriming should seemingly be practiced