The aim of this experiment was to study the effect of using tomato pomace in starter diet containing different ratios of linoleic acid to alpha linolenic acid on growth performance and blood metabolites in calves before and after weaning. For this purpose, 48 Holstein calves from 7 to 77 days old were allocated to an experimental design with 4 treatments and 12 replicate each (6 male calves and 6 female calves). The treatments were: prevalent starter diet (without oil and without tomato pomace, CON), starter diet containing 2.5% calcium salt of flaxseed oil (CFO), starter diet containing 10% dried tomato pomace (TP), and starter diet containing 2.5% calcium flaxseed oil + 10% dried tomato pomace (CFO+TP). Calves were weaned gradually from 63 to 67 days of age. Results showed that feed intake was lower ( P 0.05) in CFO group than that the CON group entire the study. While feed intake in TP and CFO+TP groups was similar to the control group. Consumption of tomato pomace or calcium salt of flaxseed oil had no effect on calves' daily weight gain and feed efficiency. Feeding calcium salt of flaxseed oil (CFO) reduced ( P 0.01) the concentration of ruminal ammonia nitrogen. Calves fed calcium salt of flaxseed oil had lower acetate ( P 0.05) and higher ( P 0.01) propionate ratio in ruminal fluid sample. The mean of feces score in CFO calves was higher ( P 0.05) than the CON group. Blood glucose level was affected by experimental diets at 77 days of age and TP group had highest ( P 0.01) blood glucose concentration. Blood insulin levels were affected by the treatments entire the study and group of CFO+TP had highest ( P 0.01) level of insulin. Concentration of blood albumin and globulin, and the ratio of albumin globin were not affected by the treatments throughout the study, but the TP group had highest ( P 0.05) concentration of blood total protein. The blood concentration of triglycerides, cholesterol, HDL, LDL and VLDL and also blood MDA, GSH-px, and TAC were not affected by the treatments. Concentration of SOD enzyme was affected by the treatments throughout the study and its level was highest ( P 0.01) in the TP group. Some of parameters including erythrocytes count were affected ( P 0.01) by the treatments. Also, the ratio of neutrophils to lymphocytes in the differential count of blood cells was affected ( P 0.01) by the treatments. In overall our results study showed that supplementation of starter diet with 10% of dried tomato pomace had no adverse effect on feed intake, but the presence of 2.5% of calcium flaxseed oil in diet reduced calves' feed intake, and calves fed the two additive had similar performance with CON group. Moreover, using dried tomato pomace in starter diet improved the ruminal fermentation performance of calves. Key words: Tomato pomace, Calcium slat of flaxseed oil, Growth performance, Holstein calf