The purpose of this thesis is to further study the endoprime modules as one of the special classes of quasi-Baer modules. As a module theoretic analogue of a prime ring, we characterize an endoprime module via its endomorphism ring and a weak retractability condition. It is shown that any direct summand of an endoprime module is an endoprime module. A characterization is obtained when a direct sum of endoprime modules is an endoprime module. It is well known that every prime ring is semicentral reduced. We prove that a column (and row) finite matrix ring over a semicentral reduced ring is also a semicentral reduced ring. Consequently, it is shown that a column (and row) finite matrix ring over a prime ring is prime. Applications and examples illustrating our results are provided.