Drought is responsible for major reductions in grain yield of crop species, including oilseed crops. Drought-imposed reductions in grain yield are due, partially, to suppresion of the absorption of nutrients by the plant roots. This study was, thus, aimed at studying the effects of water deficit on morpho-physiological attributes, grain yield and seed oil of five sesame genotypes (Yekta, Naztakshakhe, Dashtestan, Varamin and Ultan) at the presence of foliar application of Fe-sulfate in the Research Farm, Isfahan University of Technology, Isfahan, Iran in a 3-replicate split-factoriel randomized complete block field experiment. Two levels of irrigation (i.e. depletion of 60% and 90% of available soil water) where chosen as main plots, two Fe levels ( i.e. 0 and 4 mg kg -1 of FeSO 4 solution) and the five genotypes as sub plots. Water deficit led to decreases in relative water content, chlorophyll a, chlorophyll b, and carotenoids cocentrations, leaf area index, net photosynthetic rate, grain yield and grain yield components (including capsules/plant, branch/plant and seeds/capsule), whereas it led to increases in proline and electrolyte Leakage, and with damage to the cell wall reduced membrane stability index. Foliar application of ferrous sulfate under conditions of drought stress generally increased many of the measured traits, such as chlorophyll a, chlorophyll b, and carotenoids concentrations, relative water content, leaf area index, net photosynthetic rate, proline concentration, yield and yield components (i.e. number of capsules/plant, seeds/capsule, branch/plant 1000-grain weight). Genotypes differed in terms of the degree of modification in various traits in response to water and Fe treatments. Foliar application of Fe could increase sesame seed yield and oil yield in both control and drought stress conditions. Foliar-applied Fe appeared capable of mitigating the adverse effects of drought stress and offseting part of the reduction in grain yield in drought conditions. According to the Stress Tolerance Index and Geometric Mean Productivity, Dashtestan and Varamin genotypes with high yield in both stress and non-stress conditions were found to be the most resistant genotypes and Yekta and Ultan genotypes with lowest yield in drought stress and control conditions were detected as the most sensitive genotypes to water-limited enviroments. Key words: Sesame, Fe-sulfate, drought stress