Allium hirtifolium Boiss (Persian shallot), called “Moosir” in farsi, is one of the medical and industrial species in Iran. Due to high pressure on its natural habitats by harvesting for food and medicinal consumption, it is necessary to domesticate it for commercial prodution. Persian shallot is poor competitor against weeds. So, its response to some herbicides were investigate for two years in the field. This research was carried out during autumn 2015 to summer 2017 as randomized complete block design with three replications. The treatments consisted of 19 weed control scenario along with two weedy and weed free controls. Herbicide treatments included, application of pre plant soil incorporated (ppi) of Trifluraline(Treflan) in three doses (2, 2.5 and 3 liters per hectare), application of Trifluraline(Treflan) in water irrigation at establishment stage of persian shallot in three doses (2, 2.5 and 3 liters per hectare), pre emergence application of Oxadiazone (Ronstar) in three doses (2, 2.5 and 3 liters per hectare), post emergence application of Oxadiazone, bentazone (Bazagran) and oxadiargyl (Top star) in three doses (2, 2.5 and 3), (2, 2.5 and 3) and (3 and 3.5) liters per hectare respectively. Post emergence application of oxyfluorfen (Goal) (1.5 liter per hectare) and split application of Oxyfluorfen (Goal) (0.75+0.75 liter per hectare) at 2 leaf stage of Persian shallot and 20 days after that. Hand weeding was done in the control plots each week during the growing season. Weed samplings were done 15 and 30 days after application of post emergence herbicides and at the end of the growing season by using a 0.5 × 0.5 m quadrats. Weed species were determined. Height, density and dry matter of each weed species were also measured. Crop traits including crop phytotoxicity, fresh and dry weight of bulb and bulblet, bulb and bulblet diameter, plant height and crop yield were calculated. Descurainia sophia (Flixweed) was the dominant weed in the experimental plots in both years. Hand weeding caused complete weed removal and resulted the highest crop yield. Oxyfluorfen herbicide in both rate (750 cc and 1.5 liters per hectare) caused the highest crop phytotoxicity. Whereas, Bentazone and Oxyfluorfen produced the highest crop yield. Based on the results of this study, Post emergence application of Bentazone (2.5 and 3 liter per hectare), Oxadiazone (3 liter per hectare) and Oxyfluorfen (1.5 liter per hectare) may be recommended for weed control in commercial production of Persian shallot. Keywords: Persian Shallot, chemical weeds control, herbicide tolerance