Due to their biodegradation characteristics, similarity in composition with natural bone tissue and high biocompatibility, porous Beta Tricalcium Phosphate (?-TCP) ceramics are widely used in bone tissue replacement. Due to its excellent properties like high fracture toughness, Forsterite is a proper substitute for hydroxyapatite. Because of their improved properties such as grain size and surface energy, Forsterite nano ceramic unlike micron-sized Forsterite, is bioactive and is able to form apatite in simulated body fluid and increase osteoblast adhesion, proliferation and osteointegration, thus guarantee prolonged life for the implant. In this study, beta tricalcium phosphate-forsterite nano composite foams for tissue engineering applications were fabricated. (?-TCP) and forsterite nano powders were fabricated using sol-gel and mechanical activation methods, respectively. With adding 0, 5, 15 and 25 wt% forsterite to (?-TCP), beta tricalcium phosphate-forsterite nano composite foams were fabricated using gel-casting method. X-ray Diffraction (XRD) analysis was used for structural and phase evaluation of foams. Scanning Electron Microscope (SEM) was used to determine pore size and morphology. To determine the grain size of synthesized powders and foams, Transition Electron Microscope (TEM) was used. Compresion Test was used to determine mechanical properties of the foams. In order to evaluate the bioactivity and biodegradation, the foams were soaked in simulated body fluid (SBF) for 28 days. Scanning electron microscope (SEM) was used to evaluate the apatite layer formation in the pores. To determine the dissolution level of Calcium, Phosphorous and Magnesium ions and biodegradability of foams in SBF, Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES) analysis was used. Results confirmed the successful fabrication of nano composite foams. Prepared foams possess 70 – 80% porosity with the mean pore size of 200-600 µm and grain size of about 60 nanometers. The results showed that by increasing wt% of forsterite in foams the mechanical properties also increased. Compression strength increased from 0.94 MPa for ?-TCP foam to 1.77 MPa for foam containing 25 wt% forsterite. In-Vitro bioactivity tests proved that the foams are bioactive and after soaking in SBF bone-like apatite was formed on the surface of the foams. It was concluded that biodegradation of the foams can be controlled with changing ?-TCP to Forsterite ratio. According to the results, these foams can be a suitable candidate for bone tissue engineering and drug delivery applications. Keywords : Forsterite, Tricalcium Phosphate, Nanostructure, Nanocomposite, Tissue Engineering, Bone Scaffold, Gel Casting, Foam