The objectives of this study were to 1) estimate variance componets and phenotypic and genetic trends for persistency, 2) estimate phenotypic and genetic correlation between profitability and persistency and 3) calculate economic value for milk persistency in Holestein dairy cattle population of Iran. In order to estimate genetic parametersand trends forthe persistency, a total of 2487378 milktest - day records of 336,164 first-calving Holstein cowsfrom2581 herds that calved during the years 1992 to 2012were used. The estimated parameters of Wood function were used to calculate persistency. Fixed environment effects were examined by SAS software. Variance components and heritability were performed using Wombat software on the base of univariate animal model.Additive genetic and phenotypic variance and heritability were estimated to be 0.03, 0.37 and 0.08, respectively . Genetic and phenotypic trends were 0.022 and 0.01, respectively and both of them were statistically significant (P 0.05). The results of current study showed that the persistencyof Iranian Holstein cowsover these years had a favorable and positive genetic and phenotypictrend.To calculate the economic value, profitabilty and persistencyrecords belonging to182,521first-calving Holstein cows from 2000 to 2011 were used.To do this, revenues, costs and profitabity were calculated in term of per cow per year that were 65,581,118, 37,083,615 and 28,497,503 IRls, respectively. Then, anual profitabilty was regressed on persistency to give an estimate of economic value using multiple analysis of covariance, generelized linear model presidure (Proc GLM) of SAS software. The conomic value per standard deviation of persistancy was estiamted to be 1,196,750 IRls. By means of BLUPF90 on the base of a bivariate animal model, phenotypic and genetic correlation between profitability and persistencywere estimated to be 0.04 and 0.58, respectively. Obtained results in the research can be useful in evaluation and determinatio of breeding programs for milk persistancy in Holestein dairy cattle population of Iran. Keywords: variance components, milk production traits, heritability, economic value