In first section of this study a novel molecularly imprinted electrochemical sensor for sensitive determination of carbamazepine was developed. The thin film of molecularly imprinted sol-gel polymers with specific binding sites for carbamazepine was cast on pencil graphite electrode by electrochemical deposition method. The resulting composite was characterized by electrochemical impedance spectroscopy (EIS) and cyclic voltammetric techniques (CV). The interaction between the imprinted sensor and target molecule was observed by measuring the current response of the oxidation–reduction of the [Fe(CN) 6 ] 3- /[Fe(CN) 6 ] 4- as a probe, on the electrode. Under the optimal experimental conditions, the response peak current was linear to the concentration of carbamazepine in the range from 5 to100 nM and 100 to 1000 nM the detection limit was 0.7 nM and RSD was 4.5 %. This imprinted sensor was successfully applied to the determination of carbamazepine in human plasma and tablet samples. These results have revealed that the imprinted sensor fulfilled the selectivity, sensitivity, speed and simplicity requirements for carbamazepine detection and provided possibilities of clinical application in physiological fluids. In second section of this study an efficient electrocatalyst for hydrogen evolution has been developed base on Co-Ni nanoparticles modified reduced graphene oxide nanoflakes. Electrochemical properties in 0.5 M H 2 SO 4 solutions have been investigated by the polarization measurement and electrochemical impedance spectroscopy (EIS) technique. The electrodes exhibit high catalytic activity for hydrogen evolution with a low over potential, a high current density, long term stability and retain high catalytic performance.
