Salinity and drought are of the most common environmental stresses that endangered the successful production of agricultural crops. Considering that a large part of under cultivation farms of common agricultural products are located in arid and semi-arid regions of Iran and these plants undergo adverse environmental conditions, increasing plant potential in resisting environmental stresses ariginating from water shortage and excess of salts in soil is important inregard to decrease. Biological methods based on the use of the potential of beneficial soil organisms in establishing symbiotic relationships with plants, through changing the genetic of structure of crops and other plants, can increase their yield per unit area and provide the possibility of their cultivation in dry soil or in climates with abiotic and biotic stresses. This research investigates the effect of P.indica inoculum on various growth indices of rice under salt and drought stress. For this purpose greenhouse experiment was undertaken using a completely randomized plan with factorial performance method with treatments including fungal (inoculated and non-inoculated), salinity (0, 50 and 100 mM sodium chloride), drought (%100AW, %50AW and %25AW) in Research Center of No-Soil Cultivation of Isfahan University of Technology. The experiments of salinity and drough were done at three and four replication and in the condition of hydrophonic and pot caltures respectively. The result showed that shoot and root dry weights of inoculated plants with P.indica were higher than the control plants in all salinity treatments. The concentration of Sodium in root and shoot most treatments had an increasing trend in most treaatments that in inoculated plants due to inceresing uptake of Potassium instead of Sodium, this increasing trend was less than non-inoculated plants. The concentration of elements like nitrogen, magnesium, calcium, copper, zinc, iron and organic carbonin inoculated plants with P.indica had significant increase compared to non-inoculated plants in salt stress conditions. The increase in salt stress resented in increasing the activity of Catalase Enzymes, Ascorbate Peroxidase, and Guaiacol activity and also some compound like Soluble Carbohydrates and Proline in all treatments inoculated plants with the fungi. Increasing salinity stress decreased photosynthesis pigments in all plants that the reduction in the inoculated treatments was lower than other treatments. The results of drought experiment showed that with increasing drought, dry shoot and root dry weights decreased in all plants and this decrease was lower in inoculated plants compared with the others. Incensement of drought stress reduced the concentration of macro and micro soluble elements in all treatments and the reduction in inoculated treatments was lower than other treatments. Antioxidant Enzymes activities, Carbohydrates and proline concentration increased with increasing drought stress that this increase was higher in inoculated treatments. Increased drought stress reduces photosynthetic pigments in all treatments that this decrease was lower in inoculated treatments. Keywords : Keywords: mushrooms Piriformospora indica, rice, salt stress, drought stress, antioxidant enzymes