It is beyond dispute that the human population is ageing. This trend is emerging around the globe, and will bring several challenges for healthcare technologies. Actually, many of those challenges are already present in our daily living: malformations, accidents, chronic infections, and end-organ failure, that usually occurs during the final stages of degenerative disease. It is clear that a replacement for organ and organ tralantation has been developed, but because of population growth. , this is a time that tissue engineering can come into the subject. The next-generation of treatment in bone diseases will be scaffolds and tissue engineered. In tissue engineering construction needs to be driven by a personal medicine approach and must integrate a range of biological and physical properties for optimal bone regeneration. The tissue engineering method consists of a combination of cells, scaffolds with biological materials, culture conditions of biochemical compounds and physical stimuli for encouraging bone formation. The purpose of this research is to model and design scaffolds composed of gelatin/ polycaprolactone fibers layers containing hydroxyapatite and graphene nanoparticles for use in bone tissue engineering. At first, optimal conditions for the production of polyacroplottic /gelatine scaffolds were investigated in different conditions. By performing mechanical and biodegradability tests, three optimal samples were selected. Due to the wide range of materials used in the preparation of bone scaffolds, we tried to use hydroxyapatite and graphene nanoparticles. These nanoparticles improve the mechanical properties and cell growth. Polycaprolactone/gelatin/hydroxyapatite/graphene scaffolds were prepared. Evaluation of mechanical and biological properties are the main goals of this research. In this regard, attempts were made to study for properties of tensile and compressive strength of scaffolds containing nanoparticles and those without nanoparticles, and to consider mechanical and biological behavior similar to true bone. Based on the results, the addition of hydroxyapatite and graphene reduces diameter and porosity, improves the biological and mechanical properties. Also, according to the compressive strength test, the scaffolds showed modules in the range of the actual compressive bone modulus.