Development of a robust control algorithm for asymmetric buildings due to randomness of ground excitations and torsional behavior has been always a significant challenging task in vibrations control of structures. While the control algorithm in a simple approach could be designed ignoring the dependency of stiff and flexible edges’ Engineering Demand Parameters (EDPs), the present research aimed also to develop a control strategy that mitigates simultaneously asymmetric edges inelastic responses of plan-asymmetric buildings equipped with Magneto-Rheological (MR) dampers. Hence in this dissertation intelligent algorithms including Coupled and Uncoupled Fuzzy Logic Control algorithms integrated with non-dominated sorting genetic algorithm-II (NSGAII) and also a new adaptive model base control strategy using the advantage of inelastic static pushover analysis as an offline input data with Multi-Input Multi-Output (MI-MO) application have been developed and examined. The effectiveness of the proposed controllers on the inelastic seismic behavior of smart plan-asymmetric one- and multi-storey structures were evaluated under various strong and ordinary ground motions. To take inelastic behavior of controlled asymmetric building’s members into account the fiber elements modeling was employed. Furthermore robustness of the proposed adaptive strategy due to randomness direction of two-component ground motions was evaluated. Effect of distribution of dampers on the inelastic torsional response of multi-storey asymmetric moment frame buildings was considered and used to determine optimal location of dampers for 3-storey buildings while earthquake directionality effects was considered. In order to alleviate all difficulties to design a proper actuator location for a nine-story building and attain the desired level of performance, the NSGAII algorithm was applied considering eak inter-story drift ratio and peak floor rotation and the base shear force as the three objective functions for the optimal design problem. Key Words : Asymmetric building, nonlinearity, adaptive control, MR damper, earthquake directionality