In this thesis, Cu(II) and Zn(II) metal complexes with the non-steroidal anti-inflammatory drugs mefenamic acid and diclofenac sodium have been synthesized and characterized in the presence of nitrogen donor ligand isothiocyanate. mefenamic acid and diclofenac sodium act as deprotonated ligands coordinated to metal ions through carboxylato oxygens. The complexes were identified and fully characterized by elemental analysis and spectroscopic studies (IR, 1 H-NMR and UV–vis ). Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most frequently used medicinal drugs used as analgesic, anti-inflammatory and antipyretic agents Additionally, NSAIDs have exhibited chemopreventive and anti-tumorigenic activity by reducing the number and size of carcinogen-induced colon tumors and exhibiting a synergistic role on the activity of certain antitumor drugs .Mefenamic acid (Hmef) and sodium diclofenac (Nadicl), belong to the NSAID group of phenyl alkanoic acids. They exhibit favourable anti-inflammatory, analgesic and antipyretic properties. In this work, we have designed and synthesized new Cu(II) and Zn(II) complexes. The IR spectra of all complexes show a strong absorption due to the isothiocyanate Ligand. The elemental analysis results of the prepared compounds are in a good agreement with the calculated values. On the other hand, the aim of this paper is to synthesize new Cu(II) metal complexes and in vitroresearch of their antibacterial activities. The synthesis and evaluation of the biological activity of the new metal-based compounds is the field of growing interest. The complexes were tested for in vitro growth inhibitory activity against Escherichia coli and Bacillus thuringiensis, were found to possess significant Activity.