: In this project, the hydrodynamics of micro particles and nano particles have been investigated experimentally and simulated. Sieve test methods have been used to obtain the sand diameter and SAXS analyse to obtain the diameter of the nanoparticles. The two-phase Eulerian method has been used to simulate solid-gas fluid beds. After validation the simulation results with the average error of 10% for the pressure drop, different simulation for draft tubes with different sizes and at different distance above the inlet orifice has been done to selecting the best draft tube and to observe its effect on the bed hydrodynamics. According to the experimental results, sand particles with lower density than nanoparticles have higher pressure drop and higher minimum spouting velocity. The effect of specularity and restitution coefficients on the pressure drop in simulation resaults have been investigated. To simulate the nanoparticles due to the high density and the low solid volume fraction at about 0.016, the effect of drag force on the simulation results was investigated using Gidaspow and RUC drag models. RUC model is not defined in Fluet so this model has been coded with C and the UDF has been defined for software. The results, especially volume fraction contours, showed that this method predicted the hydrodynamics of the bed better and showed differences between hydrodynamic of the nanoparticle and the sand spouted bed. Keywords: spouted bed; nanoparticles; drag force; draft tube; simulation; pressure drop