The problem of lubricant and wear of cam and follower is one of the most challenging issues in the industry. Effects such as transient changes of parameters, along with the compression of the lubricant layer, the elastic deformation of the surfaces, the change in the lubricant properties with pressure and temperature, are simultaneously present in this contact. In this research, contact of cam and follower has been replaced with contact of two cylinders, radii of which as well as the applied load change during contact. The kinematic and dynamic analysis of the mechanism was studied and the variation of the equivalent curvature radius, slip speed and force applied to the contact surface were investigated. Subsequently, the set of elasto-hydrodynamic equations governing the problem of lubrication of the follower and cam mechanism was studied. In this set of equations, the effects of elastic, plastic and elastoplastic deformation of asperities as well as temperature variations of the surface and its effect on the viscosity of the lubricant are considered. Curve fitting method was used to obtain changes in the parameters of the lubrication problem, which resulted in the changes in the thickness of the lubricant layer, the percentage of the load carried by hydrodynamic film and by asperities. The variation of the coefficient of friction and the surface temperature and the weight loss are predicted by the presented model .The model predictions were compared to the experimental data obtained from the test rig made in Isfahan University of Technology. In this rig, an eccentric disk is used as the cam and a flat disk as the follower. The wear loss of this mechanism under different applied loads was measured using a digital scale. The model predictions were shown to be in good agreement with the experimental data Keywords : cam follower mechanism, Elastohydrodynamics lubrication, Surface roughness, Asperiti, Wear rate, Friction coefficient