Herein, application of copper nanoparticles supported on silica surfaces as efficient catalysts were studied in carbon-carbon, carbon-nitrogen and carbon-sulfur bond formation under conventional heating conditions in an oil bath. First, copper (I) nanoparticles activity supported on the silica surface of in the Sonogashira cross-coupling reaction were studied. The yields under optimized conditions of using KOH as base, DMF as solvent at 135°C temperature under N 2 gas were good. In the next section, the activity of copper nanoparticles supported on the surface of silica in the amination reaction was studied. The obtained product under optimized conditions of using K 2 CO 3 as base, DMF/H 2 O (1:1) as solvent at 100°C temperature under N 2 gas were good. Results showed that copper supported on the surface of silica has high efficiency in the two cross-coupling reaction. Finally, the activity of copper nanoparticles supported on the surface of MCM-41 was studied in the synthesis of benzyl phenyl sulfides. The used catalyst in this reaction has good activity. The obtained yields under optimized conditions of using K 2 CO 3 as base, H 2 O/EtOH (1:1) as solvent at 100°C temperature were good.
