In this project, a series of novel chiral and biodegradable poly(amide-imide)s (PAI)s based on different amino acids, were synthesized. For this purpose at first trimellitic anhydride and L -amino acids ( S -valine, L -alanine, L -isoleucine, L -methionine) have been used for the preparation of optically active diacids .These diacids react with 3,5-diamino- N -(pyridin-3-yl)benzamide via direct polycondensation by using the molten tetrabutylammonium bromide (TBAB) as a green solvent instead of conventional organic solvents and used triphenyl phosphite (TPP) as a condensing agent. The resulting PAIs were obtained in good yield and exhibited inherent viscosities ranging from 0.31 to 0.46 dL/g. The chemical structure of polymers was confirmed by FT-IR, 1 H-NMR spectroscopy, elemental analysis and specific rotation. Thermal properties of polymers were studied by TGA curves. In the next project, biological and biodegradability properties of synthetic monomers and polymers were investigated. In the end project, novel series of PAI/organoclay/TiO 2 nanocomposites (NC)s has been synthesized. At first, PAI containing phenylalanine amino acid was synthesized via direct polycondensation of N,N' -(pyromellitoyl)-bis-phenylalanine diacid with 4,4'-diaminodiphenylsulfone. Then, different percentages of TiO 2 nanoparticle and organoclay were added to PAI. The nanostructures and properties of the PAI/organoclay/TiO 2 NCs were investigated using FT-IR, XRD, FE-SEM and TEM techniques. TGA results indicated that the addition of organoclay and TiO 2 into the PAI matrix increases in the thermal decomposition temperatures of the resulted BNCs.