In this thesis, due to the importance of nanotechnology in the development of efficient drug delivery systems, at first, magnetic nano-certification of Zncofe 2 o 4 was analyzed by the thermal solvent method on the surface of the Graphene oxide prepared by Hummer method. Cucurbit [6] Uril was prepared. In order to improve solubility, functional groups of hydroxyl were placed on Cucurbit. To connect two compounds prepared, ZnCoFe 2 O 4 -GO Nano Composite was modified by glutamic acid. ZnCoFe 2 O 4 -GO – Glu-(HO) 12 CB [6] was prepared from the reaction of composition in the final composite environment. Naringin was selected as a medicinal model and its interaction with BSA and DNA biomolecules was assessed using different spectroscopy and microscopic methods. In order to study the potential of the obtained composite drug, Naringin release was evaluated in the external environment under different temperature and pH conditions. In this study, nano Composite ZnCoFe 2 O 4 -GO – Glu-(HO) 12 CB [6] was prepared and the loading rate of naringin on nano-composite ZnCoFe 2 O 4 -GO – Glu-(HO) 12 CB [6] and its release of this nanocomposite was investigated at different temperature, concentration and pH. The nano-composite particle size ZnCoFe 2 O 4 -GO – Glu-(HO) 12 CB [6] was 17 nm. Due to having very high groups of OH -1 level in. Nano Composite ZnCoFe 2 O 4 -GO – Glu-(HO) 12 CB [6] and the high groups of OH -1 and H 1+ in naringin, when placed in acidic environment, by forming OH +2 , hydrogen interaction is weakened and causes the drug to be relieved gradually from the substrate, the maximum drug release in the PH = 5.2 and the temperature of 45 ° C.