The Nitrogen-containing heterocycles (N-heterocycles) are omnipresent in life processes and the synthesis of these type of heterocycles represents a substantial organic chemistry research effort and resonates across numerous disciplines, including the total synthesis of natural products and medicinal chemistry. In this Dissertation, Fe 3 O 4 and other ferrites MFe 2 O 4 (M = Ca, Co, Cu, Hg, Mg, Mn, Ni, Sn, Zn) nanoparticles by a low-cost conventional coparticipation method and sulfur-doped graphene by chemical vapor deposition were obtained and apply as efficient, reusable, and environmentally benign heterogeneous catalyst for heterocyclic synthesis. First, the magnetite nanoparticles modified by blended gelatin and ?-carrageenan polymers and applied as heterogeneous catalyst for the three-component Biginelli cyclocondensation (dihydropyrimidinones preparation) reaction. Also, the chiral inductivity of this catalyst on the enantioselectivity of the obtained products was investigated by enantiomeric excess measurement. The as-prepared catalysts were characterized in detail by conventional techniques, such as X-ray powder diffraction, Transmission Electron Microscope, Field-emission Scanning Electron Microscopy, Raman spectrum and Fourier Transform Infrared Spectrometry.
