Today Electrodeionization (EDI) technology widely used for producing ultrapure water for various applications in the nuclear, pharmaceutical, electronics and semiconductor parts, aerospace, laboratories, and chemical industries. Also it utilized for ion separation in low concentration solutions. Accordingly, Wafer Enhanced-Electrodeionization (WE-EDI) is an improved technology which immobilizes resins into wafers allowing for a significant expansion in its applications in various processes especially for ultrapure water production and ion selective removal by eliminating some of the disadvantages and problems due to a decrease in internal and external channeling and leakage. In this study, investigating and comparing of five innovative methods of Ion exchange resin wafers manufacturing by using sodium alginate as a natural polymer and characterization of them such as production process, porosity, water content, ion exchange capacity and, etc has been done. In this context, five methods including floating alginate tablets in calcium solution, floating alginate tablets consisting insoluble calcium salt in the water, increasing alginate suspension viscosity by dilute calcium solution and framing, increasing alginate/gelatin suspension viscosity and framing by temperature change and framing alginate suspension and increasing viscosity by partial drying have been studied and finally the framing alginate suspension and increasing viscosity by partial drying is chosen as optimum production process. So this wafers has been characterized. Wafers produced by optimum method in compare with typical resin wafers which mainly used synthetic polymers like polyethylene as a resin binder substrate, have increased average of ion exchange capacity more than 13.2 percent and maximum of ion exchange capacity more than 75.8 percent. Also by porosity between 60 to 90 percent, these wafers could increase porosity average about 40 percent that it, in turn, is a significant improvement in wafers characteristics. In addition to ease of making, time and operation costs of optimum production method was less than others. These wafers show the desirable stability, flexibility, mechanical strength and chemical and absorption properties. Key words Electrodeionization (EDI), Ion selective removal, Resin wafer, Sodium alginate.