Isfahan is one of the most polluted cities in Iran due to the existence of various polluting sources as well as special geographical conditions and topography. Industries, traortation, household and commercial pollutants are the main sources of air pollution in Isfahan. Particulate matter with an aerodynamic diameter of less than 2.5 microns (PM2.5) has serious effects on human health, as these small particles can penetrate the lungs and adversely affect their function. Considering the relationship between these suspended particles and the possibility of their pathogenicity, this study aims to (1) investigate changes in the incidence of PM2.5-related respiratory diseases during the years 1397-1393 and (2) prepare a standard ratio of incidence and relative risk Respiratory diseases are defined and performed based on the concentration of the mentioned suspended particles in Isfahan. For the first purpose, PM2.5 concentration data, measured in 8 air pollution monitoring stations of Isfahan General Department of Environmental Protection and the number of hospitalized cases of asthma, lung cancer, chronic obstruction of the lungs and shortness of breath from Al-Zahra Teaching and Medical Hospital Isfahan, data were collected and analyzed and time trend was analyzed using ggplot package in R statistical software. For the second purpose, after receiving the information of patients with respiratory asthma, lung cancer and chronic obstruction of the lungs, the patient distribution layer was prepared in the format of file format (shp) in ArcGIS software. Also, the results of previous studies were used to distribute PM2.5 concentration based on LUR model and PM2.5 concentration zoning. Then, standard incidence ratio and relative risk maps adjusted for 15 urban areas using Bayesian spatial models BYM and CAR in R3.1.2 and OpenBUGS software, as well as maps of respiratory disease vulnerability by combining patient density layers and PM2.5 concentrations in Arc Map environment created. Based on the results of time series, the significance of correlation coefficients for different delays of PM2.5 series increased. The highest standard incidence rates of asthma, cancer and chronic obstruction were 2.28, 1.53 and 2.82 in region 13, respectively. In addition, according to the particulate matter concentration map under the LUR model, the highest relative risk of asthma, cancer, and chronic obstruction per 10 ?g / m3 of PM2.5 was 2.19, 1.46, and 2.76%, respectively, in region 13. Received. Also, the highest relative risk in the whole study area per 10 ?g / m3 increase for asthma in men was 3.12%, for lung cancer in women 1.47% and for chronic obstructive pulmonary disease in women was 2.29%. The rates in different age groups were 24 ?, 25-64 and 65 ? 3.75% for asthma, 1.45% for pneumonia and 2.06% for chronic obstructive pulmonary disease, respectively. The relationship between respiratory patients and PM2.5 map was not significant under Kriging model. According to Asthma Vulnerability Maps, Lung Cancer, and Chronic Obstructive Pulmonary Disease, the largest percentage of areas 5 and 13 were in the highly vulnerable category. Therefore, it is suggested that appropriate management measures to control particulate matter contamination in high risk and vulnerable areas to prevent and reduce disease should be prioritized. Keywords: Air pollution, Asthma, Lung cancer, Chronic obstructive pulmonary disease, Relative disease risk, Standard incidence ratio