Given water scarcity and huge wastewater production in the country, there is an urgent need to utilize wastewater for irrigation purposes. Nowadays, drip irrigation systems characterized with high efficiency and low environmental issues, have facilitated wastewater application compared to other irrigation systems. However, these systems are faced with a major challenge i.e. emitter clogging by wastewater. The present study aims to investigate the efficacy of frequent injection of chlorine in the irrigation system to prevent biological clogging of pressure-compensating emitter with two different manufacturing technologies under treated wastewater. Treatments consisted of three levels of chlorine (10, 15, 20 mg. l -1 ), two types of drip emitters, PCJ (2 liter per hour-online) and UniRam (3.5 liter per hour- inline), two types of filters (geotextile-disk and disk). Twelve experimental treatments were tested for 6 months for a period of 600 hours. The parameters included distribution uniformity (EU), absolute distribution uniformity (EUa), christiansen uniformity coefficient (UC), statistical uniformity coefficient (Us), and relative discharge (Dra). Throughout the experiment, foregoing parameters were measured after 72 hours of irrigation nine times during of experimental period. The results indicated that in step 6 (400 hours after irrigation) effect of chlorine on all parameters wassignificant (P 0.01).The EUa and Us were affected (P 0.05) by interaction between emitter and filter, and the US was affected (P 0.05) by interaction between chlorine and emitter. For treatment, PCJ emitter, disk filter and 15 mg. l -1 chlorine concentration treatment and for treatment, UniRam emitter, geotextile-disk filter and 20 mg. l -1 chlorine concentration treatment were introduced as superior treatments. The highest reduction of uniformity was 12.92% for PCJ emitter and 5.94% for UniRam emitter under disk filter and 20 mg. l -1 chlorine concentration treatment. The highest increase of uniformity was 1% for PCJ emitter and 5.1% for UniRam emitter under geotextile-disk filter and 15 mg. l -1 chlorine concentration treatment. Using geotextile-disk filter increased uniformity index for both PCJ and UniRam emitters. Overall, both emitters had good efficiency during the experiment. In order to deal with biological clogging, chlorine injection concentration should be determined individually for every wastewater source and emitter type. Keywords : drip irrigation, wastewater, emitter clogging, sodium hypochlorite, geotextile filter