In this work, a nanocatalyst designed based on Palladium complex supported on proline amino acid-functionalized chitosan was successfully prepared and evaluated as heterogeneous catalysts. CS-Proline-Pd (II) used in carbon-carbon (Suzuki) cross-coupling reaction in aqueous media. Good yields and selectivities were observed. The nanocatalyst was investigated by FE-SEM, TEM, XRD and EDX techniques. Pd (II) in a complex form spreads on the CS support in nano scale with the average size of 9nm. The catalyst was simply recovered from the reaction mixture and recycled four times in suzuki cross-coupling reaction. The Palladium amount loaded in the CS-Proline support was measured by ICP technique. In the next section monobenzyl nicotinium Copper Chloride was produced, as the first report and employed in carbon-carbon (Sonogashira), carbon-nitrogen, carbon-sulfur, cross-coupling reactions, good yield, faster reaction time and selectivities were observed. This catalytic system showed good activities that were comparable to other palladium catalysts used in this field. All the reactions were under thermal condition and nitrogen atmosphere. The catalyst was characterized by the combination of CHNS, FT-IR, ICP, 1 H-NMR, 13 C-NMR techniques and the products analyzed by GC, GC-MS, 1 H-NMR and 13 C-NMR techniques.