In this thesis, Co (II) and Zn(II) metal complexes with thePyrazinamidemedicinal Ligandhave been synthesized in the presence of 2,2?-bipyridine and 1,10-phenanthroline.Pyrazinamide is coordinated to the metal ion through the amide oxygen and ring nitrogen.Pyrazinamide a member of the Pyrazine, is among the first-line drugs for the treatment of tuberculosis.Investigating the interaction of drugs and transition metals isan important and active research area in bioinorganic chemistry.Moreover, molecular complexes having PZA as ligand are shown to have enhancement antimycobacterialproperties.The complexes of [Co(PZA)(L) 2 ](ClO 4 ) 2 , [Zn(PZA)(L) 2 ](ClO 4 ) 2 (L=2,2?-bipyridine or 1,10-phenanthroline) have been synthesized and characterized with spectroscopic methods (IR, UV-Vis, 1 H NMR) andelemental analysis. The crystal structure of [Co(PZA)(bipy) 2 ](ClO 4 ) 2 has been determined by X-ray crystallography which reveals coordination of disordered octahedral for Co (II). Biological studies show the antibacterial activity of the complexes against Gram-positive and Gram-negative bacterial strains.