In this thesis, at the first the ligand of 4-chlorobenzoxime was prepared. It was synthesized by mixture of 4-chlorobenzaldehyd, sodium hydroxide and hydroxylamin hydrochloride in water. Benzophenone oxime was synthesized by mixture of benzophenone, hydroxylamin hydrochloride and sodium hydroxide at presence of hydrochloride acid in ethanol. Then mono and tri- nuclear complexes were synthesized respectively. ) 1 ( [Pd 3 (O,N-(C 6 H 4 C(Cl)=NO)-4) 6 ] ) 2 ( [Pd 3 (PPh 3 ) 6 ] ) 3 ( [Pd{O,N-(C 6 H 5 ) 2 C=NO}(Me 3 Py)] The complexes were identified and characterized by FT-IR spectroscopy, NMR spectroscopy and also complex 1 was characterized by elemental analysis and X-ray crystallography. In the second chapter of this thesis, the biological activity of 1 and 3 has been evaluated by examining their ability to bind to Calf thymus DNA(CT-DNA) with UV-Vis spectroscopy and CD (circular dichroism) spectra. The results suggested that both complexes interact with CT-DNA through the groove mode and follow the binding affinity order of. Moreover, to explore the potential medicinal value of the new complexes, binding interaction of 1 and 3 with bovine serum albumin (BSA) was studied at normal physiological conditions using fluorescence and UV-Vis spectral techniques. The reactivity toward protein BSA revealed that the quenching of BSA fluorescence by the complexes. The reactivity towards protein BSA revealed that the quenching of BSA fluorescence by the two complexes are static quenching, and complex 3 exhibits a higher BSA- binding ability than that of complex 1 .
