There is a great need for an optimized drug delivery system due to problems associated with local cell injury and death as well as inefficient impact of drug in vivo . Bisphosphonate are a well-established group stroked="f" filled="f" path="m@4@5l@4@11@9@11@9@5xe" o:preferrelative="t" o:spt="75" coordsize="21600,21600" 43 nm, a pore size of 4 nm and a surface area of 353.51 m 2 g -1 . Bioactivity testing suggested that MBG nanoparticles were bioactive such that they produced HCA on their surface as analysed by both XRD and FTIR. Drug release tests within 4 days showed a sustained release of AL from MBG particles. In addition, exposure of MBGs to MG-63 cells showed to be non-toxic following 6 days in culture. Therefore, the synergic effect of alendronate release capability, subsequent bioactive behavior, non-cytotoxic nature of MBGs make these particles a good candidate for bone substitutes in the local treatment of bone diseases associated with bone resorption like osteoporosis. Keywords: Mesoporous bioactive glass, sol-gel, sodium alendronate, osteoporosis.
