In this study, with the hydrothermal reduction method and the reduction agent of citric acid, superparamaneite nanoparticles substituted with zinc and magnetite substituted with zinc and manganese with a narrow size distribution were synthesized. Synthesized nanoparticles are indenified with X-ray diffraction patterns (XRD), infrared spectroscopy (FTIR), scanning electron microscopy (SEM), transmition electron microscopy (TEM), vibrating sample magnetometer (VSM), dynamic light scattering (DLS). The maximum saturation magnetization for the magnetite sample was replaced by a value of x=0.5 manganese, which was measured at about 55 emu / g. MRI images taken from samples at different concentrations of manganese at different concentrations showed that due to the large contrast produced in the images taken from the sample ZN0.3Mn0.5Fe2.2O4 it can be used as an alternative to contrast agents Such as Gadolinium to identify the cancerous masses in the early stages of the disease. To reduce the toxicity of nanoparticles synthesized under simulated conditions of the body, nanoparticles were coated with PEG polymer. FTIR, TGA and TEM tests were performed to ensure presence of coating on the surface of nanoparticles
