In this thesis, a 4-nitrophenyl cyanamide as one of phenyl cyanamide ligands derivatives with high purity ligand was first prepared. Then the Cu(II), Ni(II) and Zn complexes were synthesized and with phenyl cyanamide ligand and levodopa ligand in solid phase and solvent free then were characterized. Phenyl cyanamide ligands have a peculiarity of ?-donor, hence the ability to coordinate with the central metal from the two ends of nitrile and amine. This ?-donor peculiarity is due to the presence of three atoms in the NCN group, which creates a continuous ? system within the molecule. Another ligand that was used was levodopa, a group of catecholamines which was used for treatment of Parkinson?s Disease. The complexes of Cu(II), Ni(II) and Zn were identified with two levodopa and 4-nitrophenyl cyanamide by FT-IR, UV-vis, MS and elemental analysis methods. The anticancer effects of the compounds on the hela cancer cell line was investigated using MTT(methylthiazole tetrazolium) method