Metal complexes of a wide variety of picolinamide-based ligands have been investigated as structural and functional models of several metalloproteins, due to the essential role of metal ions in biological systems. Coordination compounds of pyridine carboxamides are amongst the most commonly occurring heterocycles in anticancer drugs. The ligands provide an O, N donor set, which when coordinated to transition metals may possess potentially useful biological activity. In This Thesis first a new carboxamide ligand (1) N-(5-metyl-thizazol-2-yl) pyridin-2-carboxamide (HMetp) was synthesized by bengin method using ionic liquid as the reaction medium. Moreover Three new (2) [Co(Metp) 2 (CH 3 OH) 2 ], (3) [Cu(Metp) 2 (CH 3 OH)] and (4) [Zn(Metp) 2 (CH 3 OH) 2 ]. H 2 O complexes of HMetp ligand were synthesized. The purity and spectral properties of the ligand and its complexes have also been investigated by elemental analysis, FT-IR, UV-Vis and 1 H NMR. The structure of cobalt and copper complexes were determined by X-ray crystallography. The coordination geometry around the central metal ion in the cobalt complex is a distorted octahedral and in the copper complex is a distorted square pyramid. In the second part the ligand-(5-metyl-thizazol-2-yl)1-Hydroxy naphto-2-carboxamide (H 2 Methn) and N-(thizazol-2-yl)1-Hydroxy naphto-2-carboxamide (H 2 thn) were synthesized by bengin method using ionic liquid as the reaction medium and have been investigated by UV–vis spectroscopy and molecular fluorescence spectroscopy. The photophysical behavior of H 2 Methn and H 2 thn ligands in the presence of different metal ions and amino acids shows that both ligands can be used as fluorescent sensor for detection of Al 3+ , Cu 2+ ions and Arginine amino acid with high selectivity and sensitivity.