In this research, copper (II) sulfide nanostructures were synthesized by refluxing and solvothermal methods. The reaction was performed using copper (II) acetylacetonat as the source of Cu 2 + , elemental sulfur as the source of S, and oleic acid as the solvent at different temperatures, molar ratios and various times. The effect of some parameters including as reaction time, and temperature on the morphology and particles size of copper (II) sulfide nanostructures were investigated. The synthesized nanostructures were characterized by X-ray diffraction (XRD), Fourrier transform infrared microscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), scanning electron field emission (FE-SEM), energy dispersive X-ray analysis (EDX ), UV-Visible spectroscopy, zeta potential and thermal gravimetry analysis (TG-DTA). Finally, The copper (II) sulfide nanostructures were used as for photocatalytic degradation of organic pigments including methylene blue, Reactive Blue 21, Reactive Red 120, and Reactive Orange 5. The results showed that the highest degradation percentage for Reactive Blue21 pigment is 99%.The surface of copper (II) sulfide was modificed by hydrophilic polyethylene glycol 4000 and the modified nanoparticles was used to release doxorubicin at pH=5.4 -7.4 in invitro condition, which monitored by UV-Vis spectroscopy in . The results showed that the drug release in acidic condition is more than that in the neutral condition.