Water scarcity has been of concern to all reclamation projects in arid and semi-arid regions such as Iran. Using abnormal water sources such as urban waste water where there are not good quality water sources available is unavoidable. Appropriate usage of urban waste water will improve vegetation condition and reduce the risk of surface and groundwater pollutions. It also contains nutritional matters that can be used by plant species; hence it reduces the cost of chemical supplements in agricultural fields. Due to sever and intense water scarcity in arid and semi- arid regions, the attitudes to urban waste water has been changed and it regarded as a valuable water sources. Using urban waste water in agriculture fields has been studied previously but there are limited studies in natural resources fields. This study aimed to investigate the effects of urban waste water on vegetation cover and some physical and chemical characteristics of soils in desert combating station of Segzi in east part of Isfahan. Urban waste water has being used in this region since six years ago to irrigate some planted areas. Six studied sites were selected considering the planted species ( Haloxylon persicum and Haloxylon persicum - Nitraria schoberi ) and irrigation types (water logged and rill irrigation methods) and each sampled areas had at least three replications. Random systematic sampling methods was used to study vegetation (vegetation cover, frequency and density of all species) in 47 sample plots with size of 10*10 m 2 . Species richness of all studied sites were measured using Margalef index and species diversity with Shannon and evenness by Simpson index accordingly. Also soil sampling was carried out by excavating some soil profiles in all sites from 0-10 and 10-30 cm of soil surface. Soil properties such as acidity, electrical conductivity, organic matter, soluble sodium, total soluble calcium and magnesium, mechanical dispersible clay and dispersible clay itself were measured in laboratory. Urban waste water samples also were analyzed and the electrical conductivity, ph, total calcium and magnesium, sodium and total dissolved solids or water hardness (TDS) of all samples were measured. Principal Component Analysis was used to interpret the soil properties changes due to irrigated methods and planted species in the studied sites. The correlations of measured environmental factors with vegetation characteristics also were determined. In order to fit species response curve to both variables of organic matters and soil salinity in two depths of 0-10 and 10 -30 cm, GLM regression analysis and Poisson distribution were used. The difference between studied sites (treated and control sites) in terms of vegetation and some soil physical and chemical properties were investigated using one way ANOVA. According to results, using urban waste water leads to significant increase of vegetation covers and soil organic matter contents accordingly. It also had a positive significant effects on soil satiability but plant diversify did not changed statistically. The sites planted with Haloxylon persicum - Nitraria scoberi and irrigated with logged irrigation systems exhibits the most vegetation covers among studied sites. The salinities (soluble salts) of some sites were increased due to urban waste water too. Comparing the studied characteristics of urban waste water with suggested global standards revealed that this water sources is not appropriate for irrigating agricultural fields but it can be used in reclamation projects of degraded lands. keywords: Urban waste water, vegetation, species diversity, soil stability, desertification combating, soil salinity