Improving health quality of agricultural products is an important subject in different agricultural sciences that has also been considered by human nutritionists. Micronutrients enrichment of agricultural products particularly cereals and reducing the amount of toxic heavy metal contamination (e.g., Cd) in these products are of the most effective and low-cost approaches to combat malnutrition problems in human. Selecting and breeding crop genotypes with high efficiency in uptake, translocation, and utilization of micronutrients are known approach to increase yield and quality of cereals. Wheat is a main staple in many Asian countries such as Iran. This greenhouse (solution culture) study was conducted to investigate Zn and Cd interaction in uptake, translocation, and some oxidative reactions in some wheat genotypes differing in Zn-efficiency. Two bread wheat genotypes ( Triticum aestivum L. cvs. Rushan and Back Cross Rushan) and one durum wheat genotype ( Triticum durum L. cv. Aria) were exposed to two levels of Cd (0 and 1 µM) and three levels of Zn (0, 10, and 20 µM) in a nutrient solution. Shoot and root dry matter yield, root and shoot concentration of Fe, Zn, Cd, and P, concentration of Zn in the leaf cell wall and xylem sap, root catalase and –SH groups concentrations, and root membrane permeability in different wheat genotypes were measured. Results showed that the Rushan genotype had higher shoot and root dry matter yield in comparison with two other genotypes. The greatest response to Zn nutrition was also observed in this genotype. Zinc nutrition increased the root dry matter yield in all wheat genotypes but increased the shoot dry matter yield only in Rushan. Zinc addition to the media resulted a significant increase in the root concentration of catalase and –SH groups. Zinc and Cd interactions in uptake and translocation were dependent on the genotype and Zn concentration in the media. Cadmium imposed oxidative damages such as decreased root and shoot dry matter yield, reduction in the root concentration of –SH groups and catalase, and a significant increase in the root membrane permeability. The severity of damage varied among wheat genotypes. The highest Cd-induced oxidative damages were found in the Rushan genotype, so that in addition to a general decrease in the root and shoot dry matter, the lowest root concentration of catalase and –SH groups as well as the highest root membrane permeability were found in this genotype. In contrast, the Durum genotype showed the highest –SH groups and catalase concentrations and the lowest root membrane permeability. Zinc nutrition could counteract the negative effect of Cd on the root and shoot dry matter yield while it had no positive effect on compensating Cd-induced damages such as reduced Key words : Trace metals, Zinc-efficiency, Wheat genotype, Oxidative stress