Today with increasing water consumption and lack of water resources, treatment of industrial waste waters to reuse these waters has been attracted very much attention of researchers. Dyeing process in the textile industries with consuming a large volume of water is one of the major sources of water pollution by dye materials. The dye pollutants are generally non-biodegradable and usually cause serious negative effects on the environment. One of the effective approaches to removal of dye pollutants is using adsorption process by proper adsorbents. The aim of present work was synthesis of sodium alginate-kaolin beads and evaluation of their performance for removal of Methylene Blue from synthetic waste water. Effects of different operating parameters (initial dye concentration, solution pH, contact time, stirring speed, temperature, and adsorbent dosage) on the efficiency of the adsorption process and its capability for removal of dye pollutant were investigated. To evaluate the effect of each parameter the experiments were designed by Response Surface Method. Using RSM 54 experiments were carried out in a batch system. According to the experimental results the highest efficiency for dye removal obtained 99.56%. Using response surface methodology, optimized adsorption conditions were achieved as follows: initial dye concentration of 4 ppm, adsorbent dosage of 1 g/L, stirring speed of 190 rpm, pH of 8, contact time of 90 min, and temperature of 27 °C. Furthermore, in a series of separate experiments the effect of salt concentration on the adsorption process was explored and it was found that increasing the salt concentration in the solution had negative effects on the dye removal. The amount of solution-pH were measured before and after the adsorption process in order to determine the zero point charge which was found equal to 6.4. In addition, kinetic, isotherm, and thermodynamic studies were carried out on the adsorption process to have a better understanding about the thermo kinetics aspects of the process. By fitting the experimental data with isotherm and kinetic models, it was observed that the adsorption process follows Freundlich isotherm (R 2 0.99) and pseudo second order kinetic models (R 2 0.99), respectively. Maximum dye removal capacity at 27°C was obtained 333mg/g. Negative values of ?G at different temperatures indicated that the adsorption process was spontaneous. Also, positive values of ?H revealed that the adsorption process was endothermic. The other thermodynamic parameter ?S had positive values showing the affinity of adsorbent for adsorbate and increasing randomness at the interface of solution and solid with some structural changes in the adsorbates and adsorbents during the adsorption process. Keywords : Adsorption; Sodium alginate-kaolin beads; Methylene Blue; Response surface methodology