The Zayandeh Rood basin has faced numerous challenges due to the lack of spatial planning and increasing loading. The aquifers have lost their ability to communicate directly with this system. While groundwater is considered as vital component of the hydrological cycle in arid and semi-arid regions. Isfahan's aquifer is one of the most important aquifers in the basin because of its geographical location with demographic, industrial, agricultural and tourist characteristics. The aquifer has been steadily increasing over the years due to the lack of adaptation between natural capacity and the desire for development. Although underground water is considered as a strategic resource in urgent situations, the continued supply-oriented management in this aquifer has achieved no achievement other than destruction. MODFLOW Groundwater Modeling was used as a tool to predict the future of the aquifer. After the numerical model was prepared, calibration steps were performed in a steady state, 13-year-old blue (October 2002 to September 2015), and verification (September 2015 to September 2016) with a RMSE error of 0.472, 0.969, and 0.975 respectively. These results suggest a single option for decision makers, control and monitoring with a view to reducing the exploitation, these resources were carried out using the groundwater trail approach and the points of importer of severe stresses were identified. Another threat to groundwater is the entry of pollutants into the aquifer, using the conventional DRASTIC methodology, an aquifer's inherent vulnerability map was developed. In this model, MODFLOW results were used for three layers of depth groundwater, recharge and hydraulic conductivity. The results showed that the level of aquifer vulnerability is not high. The results of sampling of groundwater resources indicate that nitrate concentration in most aquifer areas is far from its limit. In areas such as the southeast and west of the aquifer, nitrate concentration is high and according to the orbit of drinking water wells in these areas This alarming situation makes it necessary to control and monitor the quality of groundwater. The results of these two quantitative and qualitative models indicate that the unpardonable future is anticipated if there is no change in the attitudes of stakeholders. The proposed approach is to create a new attitude based on acceptance and compliance. Should accept the effects of previous decisions and actions, governance inefficiencies and climatic constraints and adapted to the effects of climate change in the new future, Because the continuation of a series of past mistakes is exacerbating the present detrimental effects. Keywords: Groundwater Assessment, Quantitative Modeling, Aquifer Vulnerability, DRASTIC, MODFLOW