Acne is one of the most common skin diseases which is caused by inflammation of the sebaceous glands of the skin. The goal of acne treatment is reduce inflammation and activity of the sebaceous glands of the skin that Depending on the severity of the acne are used Medicinal and non-pharmacological treatments. The first choice for the treatment of mild and moderate acnes is topical treatment of acne. In consecutive years, antibiotics have been used in order to treatment of inflammatory acne. Clindamycin phosphate is one of the most popular topical antibiotics for acne treatment. In spite of the therapeutic effects, it causes dryness and inflammation of the skin, burning sensation and skin peeling. In order to decrease of side effects of using clindamycin, the drug delivery systems and using lower amounts of drug has attracted much interest in recent years. Poly vinyl alcohol (PVA) as biocompatible and biodegradable polymer with ability of electrosprying has been selected in this study as a carrier for drug. Clindamycin phosphate was loaded in PVA nanoparticles and then nanoparticles including Clindamycin phosphate were coated on the cotton fabric. At first PVA nanoparticles were fabricated from different solutions with concentrations of 1%, 1.5%, 2% and PVA solution with concentration of 1.5% was selected as the optimum condition for preparing nanoparticles. The effect of Water/ethanol ratio on morphology of nanoparticles was also investigated. Different amounts of clindamycin phosphate (5%, 10% w/w) was added to PVA solution with concentration of 1.5%. Electrospray was done at temperature of 25°C using high voltage of 12 kV and flow rate of 0.03 mL/min and resultant nanoparticles were coated on cotton fabrics placed at distance of 22cm from needle. Nanoparticles diameter was found to be 140-270 nm. Freeze-Thawing was also used for decreasing of solubility of PVA nanoparticles in water and biodegradability results showed the decreasing of biodegradation rate of PVA nanoparticles around 50%. FTIR results showed that drug did not change in the structure of nanoparticles. Moreover, X-ray results indicates freeze-thawing treatment increases the crystalinity of PVA nanoparticles. However addition of drug again decreased the crystalinity of PVA nanoparticles. Our overall results from drug delivery from nanoparticles alone and nanoparticles coated on the surface of fabric indicated that Clindamycin has more controlled release from nanoparticles when nanoparticles have been coated on cotton fabric. Keywords: Clindamycin phosphate, Poly vinyl alcohol, Electrospray, Drug release, nanoparticles
