Ammonium is one of the ionic compounds which its presence in aquaculture wastewaters causes environmental problems. Adsorption process is considered as a suitable method for the removal of pollutants from performed using different adsorbents including Zeolite. In this study, Clinoptilolite as a natural Zeolite wastewater due to its high efficiency, low expenses and simplicity that is ammonium from aquaculture wastewater. Zeolites characterization was conducted using CEC, FT-IR, and a synthetic Zeolite prepared from the stone cutting sludge were used for the removal of smaller. Also, according to the BET results, the average diameter of natural Zeolite XRF, XRD, SEM, and BET analses. Results of XRF showed that the synthetic Zeolite had lower Si/Al than natural Zeolite and therefore the size of pores were the synthetic wastewater. The batch pores was about 3.5 times than synthetic Zeolite. In this study, the ammonium adsorption experiments were performed by batch (RSM) and column methods using both Zeolites. Besdies, among the studied factors, the adsorbent dose had the adsorption experiments were carried out using five factors with five levels including initial concentration of ammonium, pH, the adsorbent dose, contact adsorption of ammonium from synthetic solutions was a second-order model for time, and temperature. According to the results, the proposed model for the maximum effect on the adsorption process. In the optimized condition, the with pseudo-second-order model (R 2 0/90) and Langmuier isotherm efficiency of ammonium adsorption by natural and synthetic Zeolite was 57.37 and 35.85 percent, respectively. Adsorption isotherms and kinetics studies showed that ammonium adsorption by both types of Zeolites were better fitted model (R 2 0/99), respectively. Adsorption thermodynamic also showed that the adsorption process was exothermic, randomly and non-spontaneity. The results of column experiments indicated that the regeneration of the adsorbent with sodium chloride was suitable. The efficiency of ammonium synthetic Zeolite, respectively. In addition, the increase of ammonia adsorption from aquaculture wastewater was 65.9% and 47.6% for the natural and concentration during the experiments showed that the increase of pH caused the in designing the systems of ammonium removal. conversion of ammonium to ammonia and therefore controlling the pH is essential Key words: Adsorption, Natural Zeolite, Synthetic Zeolite, Water pollution, Ammonium, RSM