In order to study the effects of reproductive disorders, including metritis, retained placenta, dystocia, stillbirth and twinning on production and reproductive traits and to estimate financial losses resulting from an occurrence of above mentioned disorders, biological information and economic data collected from 9 Holstein dairy herds located in Isfahan, Khorasan Razavi provinces during 2001 to 2013, were used. For the purpose, an appropriate model to describe the conditions of production in dairy farms was presented. On average, incidence rates of metritis, retained placenta, dystocia, stillbirth and twinning were %13.24, %9.69, %19.2, %4.17, and %2.71, respectively. Effects of some factors on the occurrence of each disorder were examined. The fixed effects included in the model were calving year and season, parity, and other related disorders. Logistic regression results indicated that all factors in the model had a significant effect on the incidence of disorders (P 0.001). The obtained odds ratio (OR) showed that there was a direct relationship among disorders and presence of one accelerate occurrence of others. The occurrence of each disorder had a significant negative effect on milk production and reproduction performance. All disorders significantly decreased 305 d milk production, except twinning. The highest decrease in milk production was related to retained placenta, reduced milk production by 320 kg. Metritis had greatest effect on reproduction performance, increased open days by 16.5 d. The average financial losses due to metritis, retained placenta, dystocia and stillbirths were estimated to be 11475000, 10477416, 25852227 and 10529373 Rls, respectively. Reduction in fertility was the main factor affecting costs of each investigated disorder except stillbirth that calf mortality was the most important factor. Key Words : Cost of Reproduction Disorder, Reduced Milk Production, Reduction In Fertility, Odds Ratio