: Today, biodegradable polymeric systems used in controlling drug release have been widely developed to improve the performance and efficiency of drugs. Accordingly, designing novel drug delivery systems such as textiles results in the protection of cellules against degradation and improving cellular stability due to the reduced cytotoxicity. These systems as the internal or external treatments are capable to enhance the effectiveness and safety of drugs with controlling the release rate, time and position. Some of the drug-releasing textiles include cyclodextrins, fibers containing microcapsules, micro-absorbents and electro spun nano fibers. These materials could be fabricated by conventional techniques such as weaving to produce medical textiles such as sutures, wound bandages and etc. The releasing mechanism of these systems is in accordance with physiological needs of human body. Since the drug release systems pose precise control of drug release and detect the specific target together with reducing or eliminating the side effects, they are of special interests in scientific community. Moreover, they are capable to continuously provide sufficient drug concentration to patient's body. In the present research study, the drug is deposited on cover glass and cotton fabrics and is coated by polycaprolactone and polycaprolactone/gelatin nano fibers with various thicknesses. The drug transmission through nano fibers provides better opportunities of drug release. The amount of released drug (for hydrophilic or bipolar drugs) in the presence of gelatin together with polycaprolactone increases with increasing the nano fibers hydrophilicity and accessing to water. Moreover, the surface of drug carrier substrate increases with increasing the thickness of nano fibrous web due to the more time needed for passing through the thicker nano fibrous web. This trend is shown for hydrophilic, hydrophobic and bipolar drugs. Therefore, it can be concluded that the drug release depends on various parameters such as drug type, drug chemical structure, type of carrier substrate and coating type. Drug release changes with changing each parameter. The effects of each parameter on drug release were investigated in the present research study.
